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Huu Dat
Nguyen, Ph.D.

Ph.D. Medical Science · Hallym University
Engineer in Biotechnology · Hue University (Summa Cum Laude)
Translational Neuroscience · Computational Biomedicine

Bridging wet-lab molecular neuroscience with single-cell genomics and advanced computational approaches to decode neurodegeneration — from bench discovery to clinical translation.

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Intl. Presentations

Recent Highlights

Key milestones and updates from my research activities.

Paper Published — eBioMedicine

Our work on "Pathological role of immunoproteasome PSMB8 in Parkinson's disease" is now published in eBioMedicine (2025).

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Best Oral Presentation Award

Awarded at the 5th International Conference of the Korean Movement Disorder Society (ICKMDS 2025), Jeju.

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Speaker — Synuclein Meeting 2025

Selected as speaker at the Synuclein Meeting 2025, University of Cambridge, UK.

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Speaker — ICKMDS 2025

Presenting at the 5th International Conference of the Korean Movement Disorder Society, Jeju (Oct 31 – Nov 1, 2025).

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Neuroscientist & Computational Biologist

I am a researcher at LPDN Laboratory (Department of Neurology, Hallym University Sacred Heart Hospital) working at the intersection of molecular neuroscience and computational biomedicine. My work spans from wet-lab mechanistic studies to large-scale multi-omics data analysis.

On the experimental side, my research identified the immunoproteasome (PSMB8) as a critical driver of alpha-synuclein pathology in neurodegeneration, linking proteostasis to immune activation. On the computational side, I apply single-cell RNA sequencing analysis, deep learning, and cutting-edge AI foundation models to dissect disease heterogeneity and predict cellular states across large patient cohorts.

I believe the future of neuroscience lies in combining the precision of molecular biology with the power of AI — building bridges between bench discoveries and data-driven clinical insights.

Supported by national grants (NRF, Ministry of Health & Welfare) through LPDN Lab, Hallym University, I have presented at the MDS World Congress, Synuclein Meeting (Cambridge), and ICKMDS, earning travel grants and presentation awards across three consecutive years.

Areas of Focus

My research spans three integrated dimensions: Translational Molecular Neuroscience — uncovering disease mechanisms (immunoproteasome, neuroinflammation) and translating them to clinical targets — Computational Biomedicine, leveraging single-cell genomics and AI approaches for large-scale analysis — and Stem Cell & Regenerative Biology, an early-career foundational dimension bridging cell biology and therapeutic applications.

Translational Molecular Neuroscience

Immunoproteasome & Proteostasis

Identifying PSMB8 as a key driver of α-synuclein aggregation and immune activation in Parkinson's disease — linking proteasomal dysfunction to neurodegeneration.

PSMB8 · Proteostasis · UPS · α-synuclein

Neuroinflammation & Immune Signaling

Investigating microglial activation, NLRP3 inflammasome pathways, and peripheral immune responses as drivers of dopaminergic neuron loss in neurodegeneration.

NLRP3 · Microglia · Neuroinflammation

Clinical Translation & Biomarkers

Translating molecular findings (PSMB8, NLRP3) into clinically actionable insights — through patient transcriptomic analysis, biomarker validation, and neuroprotective target identification.

Biomarkers · Drug Targets · Transcriptomics
Computational Biomedicine
Stem Cell & Regenerative Medicine

Publications

Peer-reviewed articles, conference proceedings, and collaborative research outputs.

2025
Pathological role of immunoproteasome PSMB8 in Parkinson's disease: A link between α-synuclein aggregation and immune activation
H. D. Nguyen, H. B. T. Tran, T. T. Nguyen, … Y. E. Kim*
eBioMedicine · The Lancet (2025)
IF 10.8SCIEQ1Open AccessFirst Author
View Paper
2023
Upregulation of immunoproteasome PSMB8 is associated with Parkinson's disease
H. D. Nguyen, Y. E. Kim*, et al.
Parkinsonism & Related Disorders (2023)
IF 3.4SCIEQ2First Author
View Paper
2022
Effect of Rehmannia glutinosa Libosch extract on proliferation and cardiogenic pre-differentiation of human mesenchymal stem cells
H. D. Nguyen*, T. L. Ho, et al.
BioMedicine · China Medical Univ. (2022)
IF 2.5ESCIQ1Open AccessFirst & Corresponding
View Paper
2026
CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions
Uk Yeol Moon, Young Eun Kim, H. D. Nguyen, & Hye Joung Choi*
Cellular and Molecular Neurobiology (2026)
IF 4.1SCIEQ2
View Paper
2025
Prevalence and clinical impact of alpha-synuclein pathology in idiopathic normal pressure hydrocephalus: Insights from RT-QuIC assay
J. Kook Yu, … H. D. Nguyen, et al.
Parkinsonism & Related Disorders (2025)
IF 3.4SCIEQ2
View Paper
2025
Differential Peripheral NLRP3 Inflammasome Expression in Parkinson's Disease and Multiple System Atrophy
J. Lee, … H. D. Nguyen, Y. E. Kim
Journal of Movement Disorders (2025)
IF 2.1SCIEOpen Access
View Paper
2022
Role of NLRP3 inflammasome in Parkinson's disease and therapeutic considerations
L. T. N. Nguyen, H. D. Nguyen, et al.
Journal of Parkinson's Disease (2022)
IF 4.6SCIEQ1
View Paper
2021
Influence of Piper betle L. extract on umbilical cord cells in vitro and potential treating cutaneous wound
T. C. H. Che, H. D. Nguyen, et al.
Heliyon · Cell Press (2021)
IF 3.4SCIEQ2Open Access
View Paper
2024
Immunoproteasome subunits as emerging contributors to neurodegeneration in Parkinson's Disease
H. D. Nguyen, Y. E. Kim.
Movement Disorders · MDS Congress 2024; 39(S1):S413
Journal IF 7.6SCIEConference AbstractFirst Author
View Abstract
2024
Transcriptome analysis of proteasome and inflammation in the substantia nigra of Parkinson's disease patients: the GEO database
T. L. Ho, H. D. Nguyen, E. J. Ko, & Y. E. Kim.
Movement Disorders · MDS Congress 2024; 39:S749–S750
Journal IF 7.6SCIEConference Abstract
View Abstract
2023
Distinct temporal and spatial alteration of immunoproteasome in Parkinson's Disease pathogenesis
H. D. Nguyen, Y. E. Kim, T. T. Lai, et al.
Movement Disorders · MDS Congress 2023; 38:S649–S650
Journal IF 7.6SCIEConference AbstractFirst Author
View Abstract
2020
Hue Biostimulator induces differentiation of umbilical cord mesenchymal stem cells into cardiomyocyte-like cells
H. D. Nguyen, et al.
Vietnam Medical Journal (2020)
2020
The ability to stimulate proliferation of Piper betle L. leaf extracts on fibroblast
H. D. M. Le, H. D. Nguyen, T. C. H. Che.
Proc. National Conference Biotechnology (2020)
2020
A study of the BMI and blood pressure indicators for diabetes mellitus in children in Binh Dinh, Vietnam
H. D. Nguyen, et al.
Proc. National Conference Biotechnology (2020)

Education & Honors

Education

Ph.D. in Medical Science
Department of Medical Science, Hallym University
Master in Medical Science (MMSc.)
Department of Medical Science, Hallym University
Engineer's Degree in Biotechnology — Summa Cum Laude
Hue University of Sciences, Hue University, Vietnam

Honors & Awards

2025
Best Oral Presentation Award
5th ICKMDS (International Conference of Korean Movement Disorder Society)
2025
Travel Grant
Synuclein Meeting 2025, University of Cambridge, UK
2022–24
MDS Travel Grants (3 consecutive years)
International Congress of Parkinson's Disease & Movement Disorders
2022
Honda YES Award
Honda Foundation, Japan
2021
Panasonic Scholarship
Panasonic Asia Pacific
2021
Odon Vallet Scholarship
Rencontres du Vietnam
2021
3rd Prize — Tech Innovation Contest
Thua Thien Hue Provincial Contest
2020
Prize Winner — National Scientific Research Contest
Ministry of Education, Vietnam
2019
2nd Prize — Stem Cell Innovation Contest
Stem Cell Institute, VNU-HCM