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Bridging wet-lab molecular neuroscience with single-cell genomics and advanced computational approaches to decode neurodegeneration — from bench discovery to clinical translation.
Key milestones and updates from my research activities.
Our work on "Pathological role of immunoproteasome PSMB8 in Parkinson's disease" is now published in eBioMedicine (2025).
Read Full ArticleAwarded at the 5th International Conference of the Korean Movement Disorder Society (ICKMDS 2025), Jeju.
View GallerySelected as speaker at the Synuclein Meeting 2025, University of Cambridge, UK.
View GalleryPresenting at the 5th International Conference of the Korean Movement Disorder Society, Jeju (Oct 31 – Nov 1, 2025).
View GalleryI am a researcher at LPDN Laboratory (Department of Neurology, Hallym University Sacred Heart Hospital) working at the intersection of molecular neuroscience and computational biomedicine. My work spans from wet-lab mechanistic studies to large-scale multi-omics data analysis.
On the experimental side, my research identified the immunoproteasome (PSMB8) as a critical driver of alpha-synuclein pathology in neurodegeneration, linking proteostasis to immune activation. On the computational side, I apply single-cell RNA sequencing analysis, deep learning, and cutting-edge AI foundation models to dissect disease heterogeneity and predict cellular states across large patient cohorts.
I believe the future of neuroscience lies in combining the precision of molecular biology with the power of AI — building bridges between bench discoveries and data-driven clinical insights.
Supported by national grants (NRF, Ministry of Health & Welfare) through LPDN Lab, Hallym University, I have presented at the MDS World Congress, Synuclein Meeting (Cambridge), and ICKMDS, earning travel grants and presentation awards across three consecutive years.
My research spans three integrated dimensions: Translational Molecular Neuroscience — uncovering disease mechanisms (immunoproteasome, neuroinflammation) and translating them to clinical targets — Computational Biomedicine, leveraging single-cell genomics and AI approaches for large-scale analysis — and Stem Cell & Regenerative Biology, an early-career foundational dimension bridging cell biology and therapeutic applications.
Identifying PSMB8 as a key driver of α-synuclein aggregation and immune activation in Parkinson's disease — linking proteasomal dysfunction to neurodegeneration.
PSMB8 · Proteostasis · UPS · α-synucleinInvestigating microglial activation, NLRP3 inflammasome pathways, and peripheral immune responses as drivers of dopaminergic neuron loss in neurodegeneration.
NLRP3 · Microglia · NeuroinflammationTranslating molecular findings (PSMB8, NLRP3) into clinically actionable insights — through patient transcriptomic analysis, biomarker validation, and neuroprotective target identification.
Biomarkers · Drug Targets · TranscriptomicsLeveraging single-cell sequencing, deep learning, and transformer-based foundation models to decode disease heterogeneity and predict cellular states across large-scale multi-omics data.
Foundational research in mesenchymal stem cell differentiation and natural bioactive compound-mediated cell modulation — exploring translational potential in tissue repair and regenerative medicine.
Peer-reviewed articles, conference proceedings, and collaborative research outputs.